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Psycology » Psychiatry and psychotherapy » Late-onset psychosis » Parkinson's disease and Huntington's chorea

ContentPsychosis later age:
- Presenile (involution) psychoses atrophic brain diseases: - Senile dementia of Alzheimer's type - Alzheimer's Disease - Pick's disease - Parkinson's disease and Huntington's chorea borderline disorders in later life

At the same degenerative brain disease occurs predominantly defeat of the extrapyramidal system. Starting mainly related to the age of 40-50 years after the main symptoms in the initial period resemble the phenomenon of neurasthenia (cerebrasthenia) with irritability, insomnia, mood instability. Then pretty quickly manifest extrapyramidal disorders (tremor, muscle rigidity, hypokinesia).

The disease was described by J. Parkinson (1817) called "shaking palsy." It was noted that men get sick 2 times more often than women, mental disorders are found in most patients, dementia develops in about 10% of the patients. Characterized by personality changes, irritability, impudence, pristavuchestyu, depressive manifestations. In the future, develop memory impairment, cognitive disorder.

Etiopatogenetichesky considered as a hereditary disease (autosomal dominant inheritance) with a low degree of penetrance (20-25%). Degeneration is mainly localized in the substantia nigra of the brain (nigrostriatal system).

For treatment using M anticholinergic agents - such as levodopa (madopar) MAOI-B (yumeks) and, Akatinol Memantine.

Huntington's chorea

This is a hereditary disease with the transmission in an autosomal dominant manner in which the possible DNA diagnosis (abnormal gene located on the short arm of chromosome 4).

The disease often begins after age 40, but long before its manifestation, there are signs of personality pathology. Only about a third of the psychiatric disorders appear simultaneously with neurological. At the forefront of the clinical picture are the hyperkinesis. Dementia increases gradually, long the usual ability to work, but due to the incremental impaired ability to navigate in a new environment and reduce the efficiency of the attention is suffering with a tendency to decrease. At some stage, often found in the presence of organic reducing individual phenomena complacency euphoria aspontannost.

Used for the treatment of hyperkinetic neuroleptics (haloperidol), methyldopa (lowers dopamine levels), used reserpine. The effectiveness of treatment is negligible, the disease progresses with the increase of dementia.

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