General Psychology Psychiatry Psychologists Thinkers Crib

Psycology » News » Psychiatry » Developed a new drug that can cure Alzheimer's disease

American scientists during unexpected experiment found that a cure for cancer, may help in Alzheimer's disease. This medication is well known in the pharmaceutical market as Targretin, active substance is bexarotene. The main action of this drug is aimed at the activation of protein apolipoprotein E (APOE). It is usually used in the form of cutaneous T-cell lymphoma.

According to doctors, Alzheimer's disease is a genetic disease and is associated with a mutation of the protein apolipoprotein E (ApoE) which is to excrete the protein beta-amyloid. Disruption of this protein leads to increases in the CNS concentrations amiloda beta, which in turn leads to deterioration of the patients.

Comparing these facts, scientists Case Western Reserve University in Cleveland decided to try this drug on mice suffering from Alzheimer's analogue. The first studies were carried out in 2009. It was then ordered researcher administered to the mice bexarotene. After just three days of its graduate student reported that the number of beta-amyloid accumulations in the central nervous system has decreased significantly.

Later, similar experiments were carried out on hundreds of mice, which suffered a running form of the disease. After treatment habits of these experimental animals were changed for the better. They observed positive dynamics of growth of thinking, smelling, and held a change of social behavior. Remission in mice persisted for three months. Then watching the animals were usually cast. The three-month steady state mice was already evidence that the effect of the adoption of bexarotene is fairly stable.

This drug has already been probing the on humans during the study of its effect on cancer and release the pharmaceutical market. Now, scientists plan to begin experiments on people suffering from Alzheimer's disease.

Chemist Carl Wagner suggested researcher Landreth again received bexarotene analogues. It is assumed that they may affect the beta-amyloid and the apolipoprotein E (ApoE) is more directionally. It is also planned to test in the near future.


© 2008-2019 Psychology online.: en, es, de, fr, cz